Obesity as an epidemic is a major contributor to ill-health, disability and mortality worldwide and therefore intervention is of utmost importance. Brain regions involved in the reappraisal of tasty but unhealthy foods are of special interest for the development of new therapeutic interventions for obesity. Using electroencephalogram (EEG), we visually presented food items to obese and lean individuals, while they admitted or reappraised their desire for food. During admitting the desire for low and high calorie food, obese as well as lean individuals showed higher activity in the left dorsolateral prefrontal cortex (DLPFC), whereas the right frontal operculum was involved in the reappraisal of the same food, suggesting interplay between executive control and gustatory regions. In lean participants, we found an interaction between calorie content and admit/reappraise condition in bilateral anterior insular cortices, suggesting that the anterior insula, assumed to primarily host gustatory processes, also underpins higher cognitive processes involved in food choices, such as evaluating the foods’ calorie content for its reappraisal. We also questioned how eating to satiety affects food reappraisal abilities and corresponding neuronal activity in the left DLPFC and right frontal operculum in lean and obese women. When hungry, lean women self-rated the ability to reappraise visually presented food as more difficult than allowing desire for the same food. Obese hungry women instead rated their ability to reappraise food as equally well as allowing the desire, probably suggesting hunger-related impaired self-reflection of food reappraisal abilities. In obese women frontal operculum was involved in the reappraisal of foods and surprisingly also in admitting the desire for the same food suggesting that right frontal operculum in the obese female brain underpins evaluation processes involved in regulation of food desire after eating to satiety. Therefore, the frontal operculum may in future serve as a target for non-invasive brain stimulation or neurofeedback studies that aim at modulating eating behavior in obese women towards better food reappraisal abilities.